由NIH 1R01HD097619-01A1支持
遵守康复治疗的主要障碍是患者努力的努力，由疲劳和不可逾越的努力引起的。如果一个体育锻炼感觉非常努力，可能不愿意施加所需的努力，而如果锻炼感觉不那么努力，那么可能更有可能坚持不懈。尽管基于努力的判断不同时，其在各种神经系统条件下的破坏，但负责体力努力主观估值的机制得到了有限的调查。该提案的核心假设是个人对努力的主观估值反映在她的电机皮层的固有兴奋性中，并且这种度量对疾病状态敏感。我们将在健康的人体参与者中进行实验;和一群患有多发性硬化症（MS）的参与者。我们开发了一种基于新的精选选择范式，使我们能够获得个人对努力的主观估值的精确客观衡量标准。我们将使用这种方法，结合计算建模，功能性磁共振成像（FMRI）和非侵入性脑刺激，调查负责努力主观估值的机制。在AIM 1中，我们将研究电机生理学如何影响健康参与者的主观努力估值。我们将使用经颅磁刺激（TMS）来侵入性探测参与者电机皮质的生理特性; and we will have the same participants make decisions about effort while they are scanned with fMRI, and use this data to computationally model their subjective valuation of effort and associated brain activity. These experiments will allow us to test the relationships between an individual's representations of effort value and motor physiology. In Aim 2 we will identify the mechanisms of subjective effort valuation in patients with MS. We will use TMS and fMRI to investigate the neural and behavioral representations of effort value in MS. These experiments will shed light on the neural circuits that are disrupted in individuals with MS, suffering from feelings of fatigue. Our studies will have a broad impact on the fields of decision-making and motor control by dissecting the fundamental mechanisms responsible for physical effort valuation. This work will provide an understanding of the neural mechanisms underlying disrupted feelings of effort in MS, and may eventually reveal neurobehavioral markers and neuromodulatory interventions to aid in the prediction and treatment of rehabilitation non-compliance.
该提案的目标是了解个人的固有运动皮质生理学如何影响其体质努力的行为和神经表征，以及这种关系如何破坏多发性硬化的患者，患有不可逾越的努力的感受。这项工作的发现最终可能揭示神经表达标志物和神经调节干预措施，以帮助预测和治疗康复不合规。